| 2022-01-29 15:00:0129/01/2022 |   Runcorn Linnets vs Workington AFC | 15:00:0115:00 | NPL West | NPL West 21/22 | Millbank Linnets Stadium |
| 2022-02-05 15:00:0705/02/2022 |  Workington AFC vs Mossley | 15:00:0715:00 | NPL West | NPL West 21/22 | Borough Park |
| 2022-02-08 19:45:5008/02/2022 |  Bootle vs Workington AFC | 19:45:5019:45 | NPL West | NPL West 21/22 | Berry Street Garage Stadium |
| 2022-02-19 15:00:3119/02/2022 |  Ramsbottom United vs Workington AFC | 15:00:3115:00 | NPL West | NPL West 21/22 | Harry Williams Stadium |
| 2022-03-19 15:00:4319/03/2022 |  Workington AFC vs Trafford | 15:00:4315:00 | NPL West | NPL West 21/22 | Borough Park |
| 2022-03-26 15:00:5126/03/2022 |  Prescot Cables vs Workington AFC | 15:00:5115:00 | NPL West | NPL West 21/22 | IP Truck Parts Stadium |
| 2022-04-16 15:00:1816/04/2022 |  Marine vs Workington AFC | 15:00:1815:00 | NPL West | NPL West 21/22 | Marine Travel Arena |
